RESUMO
The present study aimed to evaluate the potential for using toxicity assays with sediment samples for the detection of water pollution caused by the discharge of tannery effluents into water bodies and its application to environmental forensic investigation. The study included ecotoxicological evaluation of sediments, survey of benthic organisms in the field, as well as chromium, cadmium and lead dosage which provided data for a sediment quality triad evaluation. The sediment samples showed acute and chronic toxicity to the bioindicators, low biodiversity of benthic macrofauna and high chromium concentration, reaching up to 4365 mg.Kg-1. A close relationship was observed between the separate results of ecotoxicological sediment evaluation and the sediment quality triad. The sediment ecotoxicological assessment proved to be applicable to tracking sources of contamination related to tanneries and similar activities in environmental forensics.
Assuntos
Toxicologia Forense/métodos , Sedimentos Geológicos/análise , Poluentes Químicos da Água/toxicidade , Animais , Artrópodes/efeitos dos fármacos , Brasil , Cádmio/toxicidade , Cromo/toxicidade , Monitoramento Ambiental , Gastrópodes/efeitos dos fármacos , Chumbo/toxicidade , Oligoquetos/efeitos dos fármacos , RiosRESUMO
Abstract The present study aimed to evaluate the potential for using toxicity assays with sediment samples for the detection of water pollution caused by the discharge of tannery effluents into water bodies and its application to environmental forensic investigation. The study included ecotoxicological evaluation of sediments, survey of benthic organisms in the field, as well as chromium, cadmium and lead dosage which provided data for a sediment quality triad evaluation. The sediment samples showed acute and chronic toxicity to the bioindicators, low biodiversity of benthic macrofauna and high chromium concentration, reaching up to 4365 mg.Kg–1. A close relationship was observed between the separate results of ecotoxicological sediment evaluation and the sediment quality triad. The sediment ecotoxicological assessment proved to be applicable to tracking sources of contamination related to tanneries and similar activities in environmental forensics.
Resumo O objetivo do presente estudo foi avaliar o potencial de aplicação de ensaios de toxicidade com amostras de sedimento para constatação de poluição aquática causada por lançamentos de efluentes de curtumes em cursos d’água e seu emprego na perícia criminal ambiental. O estudo incluiu avaliação ecotoxicológica de sedimentos, avaliação da fauna bentônica local e dosagem de cromo, cádmio e chumbo que forneceram dados para avaliação da tríade de qualidade dos sedimentos. As amostras de sedimentos mostraram efeito de toxicidade aguda e crônica aos bioindicadores, baixa biodiversidade da macrofauna bentônica e altas concentrações de cromo que chegaram a 4365 mg.Kg–1. Houve uma estreita relação entre os resultados isolados da avaliação ecotoxicológica e a tríade de qualidade de sedimentos. A avaliação ecotoxicológica demonstrou ser aplicável na identificação de fontes de contaminação relacionadas a curtumes e atividades similares em perícias ambientais.
Assuntos
Animais , Toxicologia Forense/métodos , Sedimentos Geológicos/análise , Poluentes Químicos da Água/toxicidade , Artrópodes/efeitos dos fármacos , Brasil , Cádmio/toxicidade , Cromo/toxicidade , Monitoramento Ambiental , Gastrópodes/efeitos dos fármacos , Chumbo/toxicidade , Oligoquetos/efeitos dos fármacos , RiosRESUMO
OBJECTIVE: To present the fourth case report of development of a non-Hodgkin's lymphoma in a patient with active acromegaly. METHODS: We describe the clinical, laboratory, and imaging findings in a patient with untreated acromegaly in whom a large cell non-Hodgkin's lymphoma developed. RESULTS: Acromegaly is associated with several comorbid conditions. Among these is a higher incidence of several types of visceral malignant lesions, especially carcinoma of the colon. Growth hormone stimulates the hepatic production of somatomedins, such as insulin-like growth factors, which are known promoters of human growth and have also been implicated in tumorigenesis. In recent years, several cases of lymphoproliferative diseases have also been noted in patients with acromegaly. These conditions include multiple myeloma, lymphoma, and leukemia; three previous cases of non-Hodgkin's lymphoma have been described. In our patient, a 57-year-old man with acromegaly, magnetic resonance imaging of the pituitary gland disclosed a large intrasellar mass. Large cell non-Hodgkin's lymphoma was diagnosed. Six months of chemotherapy yielded complete remission. CONCLUSION: An additional case of non-Hodgkin's lymphoma in a patient with acromegaly supports the accumulating evidence of an increased risk for development of cancer in such patients.
